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ppar α agonist  (MedChemExpress)


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    Structured Review

    MedChemExpress ppar α agonist
    a Volcano plot; b Heatmap of DEGs related to liver development and hepatic lipid metabolism; c KEGG analysis; d Circos diagram showing the relationship between key DEGs and KEGG pathways; e Correlation analysis between the key DEGs and TG-VLDL metabolism-related SDMs; f qPCR validation, n = 4–5/group; g Inhibitory effect of LaCl 3 on <t>PPAR</t> α -driven luciferase activity in HEK-293T cells. Different letters indicate statistically significant differences among groups ( p < 0.0001); n = 4–5/group; h Model of how PPAR α -mediated TG-VLDL biosynthesis inhibition. Mean ± S.E.M.
    Ppar α Agonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 35 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ppar α agonist/product/MedChemExpress
    Average 94 stars, based on 35 article reviews
    ppar α agonist - by Bioz Stars, 2026-04
    94/100 stars

    Images

    1) Product Images from "Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPAR α -dependent ApoB suppression"

    Article Title: Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPAR α -dependent ApoB suppression

    Journal: Communications Biology

    doi: 10.1038/s42003-026-09697-6

    a Volcano plot; b Heatmap of DEGs related to liver development and hepatic lipid metabolism; c KEGG analysis; d Circos diagram showing the relationship between key DEGs and KEGG pathways; e Correlation analysis between the key DEGs and TG-VLDL metabolism-related SDMs; f qPCR validation, n = 4–5/group; g Inhibitory effect of LaCl 3 on PPAR α -driven luciferase activity in HEK-293T cells. Different letters indicate statistically significant differences among groups ( p < 0.0001); n = 4–5/group; h Model of how PPAR α -mediated TG-VLDL biosynthesis inhibition. Mean ± S.E.M.
    Figure Legend Snippet: a Volcano plot; b Heatmap of DEGs related to liver development and hepatic lipid metabolism; c KEGG analysis; d Circos diagram showing the relationship between key DEGs and KEGG pathways; e Correlation analysis between the key DEGs and TG-VLDL metabolism-related SDMs; f qPCR validation, n = 4–5/group; g Inhibitory effect of LaCl 3 on PPAR α -driven luciferase activity in HEK-293T cells. Different letters indicate statistically significant differences among groups ( p < 0.0001); n = 4–5/group; h Model of how PPAR α -mediated TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Techniques Used: Biomarker Discovery, Luciferase, Activity Assay, Inhibition

    a , b Representative images and quantitative analysis of liver fluorescence for each group (Control, LaCl 3 , and LaCl 3 + GW7647) at 120 hpf, n = 17–18/group; c Representative images of H&E staining in the liver sections. Red arrows indicate lipid droplets, black arrows indicate nuclear deformation, and orange arrows indicate vacuolization, n = 5/group. d , e Representative images and quantitative analysis of ORO staining in larvae, n = 15/group. The level of ( f ) TG, ( g ) VLDL, ( h ) FFA, ( i ) ALT, and ( j ) AST, n = 4–5/group. k Expression levels of PPAR α pathway-related genes for each group, n = 4–5/group; ** p < 0.01, *** p < 0.001, **** p < 0.0001, exact p values are provided in the Supplementary Data. l , m Western blot analysis of Ppara in zebrafish hepatic tissues, n = 4/group; n Schematic diagram of PPAR α in the regulation of LaCl 3 -induced TG-VLDL biosynthesis inhibition. Mean ± S.E.M.
    Figure Legend Snippet: a , b Representative images and quantitative analysis of liver fluorescence for each group (Control, LaCl 3 , and LaCl 3 + GW7647) at 120 hpf, n = 17–18/group; c Representative images of H&E staining in the liver sections. Red arrows indicate lipid droplets, black arrows indicate nuclear deformation, and orange arrows indicate vacuolization, n = 5/group. d , e Representative images and quantitative analysis of ORO staining in larvae, n = 15/group. The level of ( f ) TG, ( g ) VLDL, ( h ) FFA, ( i ) ALT, and ( j ) AST, n = 4–5/group. k Expression levels of PPAR α pathway-related genes for each group, n = 4–5/group; ** p < 0.01, *** p < 0.001, **** p < 0.0001, exact p values are provided in the Supplementary Data. l , m Western blot analysis of Ppara in zebrafish hepatic tissues, n = 4/group; n Schematic diagram of PPAR α in the regulation of LaCl 3 -induced TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Techniques Used: Fluorescence, Control, Staining, Expressing, Western Blot, Inhibition



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    Image Search Results


    a Volcano plot; b Heatmap of DEGs related to liver development and hepatic lipid metabolism; c KEGG analysis; d Circos diagram showing the relationship between key DEGs and KEGG pathways; e Correlation analysis between the key DEGs and TG-VLDL metabolism-related SDMs; f qPCR validation, n = 4–5/group; g Inhibitory effect of LaCl 3 on PPAR α -driven luciferase activity in HEK-293T cells. Different letters indicate statistically significant differences among groups ( p < 0.0001); n = 4–5/group; h Model of how PPAR α -mediated TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Journal: Communications Biology

    Article Title: Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPAR α -dependent ApoB suppression

    doi: 10.1038/s42003-026-09697-6

    Figure Lengend Snippet: a Volcano plot; b Heatmap of DEGs related to liver development and hepatic lipid metabolism; c KEGG analysis; d Circos diagram showing the relationship between key DEGs and KEGG pathways; e Correlation analysis between the key DEGs and TG-VLDL metabolism-related SDMs; f qPCR validation, n = 4–5/group; g Inhibitory effect of LaCl 3 on PPAR α -driven luciferase activity in HEK-293T cells. Different letters indicate statistically significant differences among groups ( p < 0.0001); n = 4–5/group; h Model of how PPAR α -mediated TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Article Snippet: For mechanism exploration, the same LaCl 3 exposure regimen (2–120 hpf) was co-treated with PPAR α agonist (GW7647, 1 μM; 99.45%; MCE, CAS: 265129-71-3, USA), OA (0.2 μM; 99%, Aladdin, CAS: 112-80-1, China), or MG132 (1 μM; 98%, Aladdin, CAS: 1211877-36-9, China).

    Techniques: Biomarker Discovery, Luciferase, Activity Assay, Inhibition

    a , b Representative images and quantitative analysis of liver fluorescence for each group (Control, LaCl 3 , and LaCl 3 + GW7647) at 120 hpf, n = 17–18/group; c Representative images of H&E staining in the liver sections. Red arrows indicate lipid droplets, black arrows indicate nuclear deformation, and orange arrows indicate vacuolization, n = 5/group. d , e Representative images and quantitative analysis of ORO staining in larvae, n = 15/group. The level of ( f ) TG, ( g ) VLDL, ( h ) FFA, ( i ) ALT, and ( j ) AST, n = 4–5/group. k Expression levels of PPAR α pathway-related genes for each group, n = 4–5/group; ** p < 0.01, *** p < 0.001, **** p < 0.0001, exact p values are provided in the Supplementary Data. l , m Western blot analysis of Ppara in zebrafish hepatic tissues, n = 4/group; n Schematic diagram of PPAR α in the regulation of LaCl 3 -induced TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Journal: Communications Biology

    Article Title: Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPAR α -dependent ApoB suppression

    doi: 10.1038/s42003-026-09697-6

    Figure Lengend Snippet: a , b Representative images and quantitative analysis of liver fluorescence for each group (Control, LaCl 3 , and LaCl 3 + GW7647) at 120 hpf, n = 17–18/group; c Representative images of H&E staining in the liver sections. Red arrows indicate lipid droplets, black arrows indicate nuclear deformation, and orange arrows indicate vacuolization, n = 5/group. d , e Representative images and quantitative analysis of ORO staining in larvae, n = 15/group. The level of ( f ) TG, ( g ) VLDL, ( h ) FFA, ( i ) ALT, and ( j ) AST, n = 4–5/group. k Expression levels of PPAR α pathway-related genes for each group, n = 4–5/group; ** p < 0.01, *** p < 0.001, **** p < 0.0001, exact p values are provided in the Supplementary Data. l , m Western blot analysis of Ppara in zebrafish hepatic tissues, n = 4/group; n Schematic diagram of PPAR α in the regulation of LaCl 3 -induced TG-VLDL biosynthesis inhibition. Mean ± S.E.M.

    Article Snippet: For mechanism exploration, the same LaCl 3 exposure regimen (2–120 hpf) was co-treated with PPAR α agonist (GW7647, 1 μM; 99.45%; MCE, CAS: 265129-71-3, USA), OA (0.2 μM; 99%, Aladdin, CAS: 112-80-1, China), or MG132 (1 μM; 98%, Aladdin, CAS: 1211877-36-9, China).

    Techniques: Fluorescence, Control, Staining, Expressing, Western Blot, Inhibition